Wednesday, November 9, 2011

Muscle-and-Health Diet : Build Your Body Through Middle Age and Beyond by Jerry Brainum


  One of the great things about bodybuilding is that it’s never too late to begin. Recent studies show that while the majority of sports have physiology-based age limitations, you can build and maintain muscle with advancing age. That’s not to say that adding muscle isn’t easier when you’re young. Those who train in their 20s or younger are at a distinct advantage when it comes to bodybuilding progress. They have a more potent release of anabolic hormones, more complete and rapid recovery from workouts and the ability to get stronger with less chance of injury.


   Those advantages may lead you to conclude that bodybuilding should be left to the young, but nothing could be further from the truth. The real advantages of lifting weights occur as you age. While the search for the fountain of youth continues, most scientists agree that the closest things to it are exercise and diet. The human body operates on a “use it or lose it” principle. Aging people who don’t present themselves with mental challenges often wind up with the more serious cases of mental degeneration. Those who don’t exercise their muscles may lose their ability to move.

   The body can tolerate an impressive degree of insult, such as lack of exercise and poor diet, until about age 40. That’s when all the physical and mental neglect begins to surface. Those who are out of shape at 40 often say they feel older than their chronological age. The reverse is true for those who engage in judicious exercise and diet. For them the aging process seems to slow to a crawl.

   A key aspect of maintaining fitness and health with the passing years is optimal nutrition. The same principles that apply when you’re young also apply when you’re middle-aged or older. You still need to eat all required nutrients and avoid foods that promote disease and degeneration. If you ask scientists who study aging about the best nutritional technique for delaying the aging process, many will tell you calorie restriction. That’s proved effective in a number of animal species, where reducing calories led to a slowed rate of aging and protection against most diseases associated with aging, including cardiovascular disease and cancer. The experts usually advise reducing daily calories by 30 percent or more.

   Despite the apparent success of calorie restriction in animals, there’s little evidence that such a stringent eating plan works in human beings. The first hurdle is that curbing calories to the extent demanded by a typical low-calorie plan is apt to lead to long-term failure, or what medical pros call lack of compliance, in all but the most highly motivated dieters. On the other hand, proponents of calorie restriction bristle when it’s called a starvation diet, noting that while calories are restricted, nutrients are not. Reducing required nutrients along with calories would lead to a shorter life span.

   From an exercise and bodybuilding perspective, restricted-calorie dieting is a negative. That’s readily apparent when you take a look at those who have opted for the calorie-restriction lifestyle. Without exception, they appear catabolic and painfully thin. One proud proponent of the calorie-restriction system flexes his arm in a Web site photo, evidently unaware that his biceps resembles a pea on a plate.

   Some aspects of calorie restriction that are said to help delay the aging process aren’t suitable to successful muscle building at any age. Restricting calories can decrease anabolic hormones, except maybe growth hormone—but GH alone isn’t associated with muscle size. Prolonged calorie restriction usually elevates cortisol, the primary catabolic hormone, and you don’t get enough protein and fat to support anabolic hormone function and muscular growth.

   Recent studies show that the life-span-related benefits of calorie restriction accrue from decreased cellular oxidation, especially in the mitochondria, a part of the cell that produces energy. The other beneficial aspect is less bodyfat, which leads to less whole-body inflammation. That’s noteworthy because most degenerative diseases of aging have an inflammatory component. Far from being the passive tissue it was thought to be in the past, bodyfat acts like an endocrine organ, releasing numerous substances that have potent effects on health and longevity. So the less bodyfat you have, the greater your chances of living to an advanced age.

If you’re over 40 and want to build or keep your muscle, your primary focus should be on maintaining health and preventing diseases that start in the middle years. That’s clearly what differentiates older bodybuilders from their younger peers. The young often show little concern for preventing disease. At the height of their physical prowess, they frequently turn a blind eye toward the future. All that changes when you turn 40. Even if you choose to ignore the effects of aging, they’ll soon become apparent.


   Good nutrition, however, can diminish or even slow many of the effects associated with aging. That’s why you need to know how to eat to maintain and build muscle, as well as provide a hedge against the physical and mental degeneration that would otherwise inevitably ensue.

   Start by taking stock of your present condition and setting your goals from that perspective. For example, if you have a close family member who has type 2 diabetes, your diet plan should focus on reducing bodyfat and getting nutrients that will promote insulin sensitivity, including chromium, biotin and most other vitamins and minerals. You should avoid processed carbs and other simple sugars and focus on low-glycemic- index carbs that elicit the least release of insulin.

   An exception to that rule would be the intake of high-glycemic carbs just after a workout. Research shows that taking in a carb-protein ratio of about 3-to-1 just after a workout heightens insulin release, which promotes anabolic action in muscle. The greater insulin release not only stimulates amino acid uptake in muscle for increased muscle protein synthesis but also activates the rate-limiting enzyme for muscle glycogen replenishment, which aids workout recovery considerably.

   A major advantage of keeping a close eye on carb intake is that the aging process may largely be based on resting insulin levels. Too many carbs, especially processed carbs and bad sugars, such as high-fructose corn syrup, promote not only an excessive insulin release and subsequent bodyfat but also a process called glycation, which increases deposition of sugars in connective tissue and other body proteins. Most scientists think that’s what causes the increased stiffness associated with aging. In diseases such as diabetes, which involves disordered insulin metabolism and elevated blood sugar, the process is more rapid, which is why poorly treated diabetics age at a rate three to five times faster than normal.

   A few nutrients can retard or blunt the glycation process, including lipoic acid, green tea, vitamins C, E and B6, niacin and L-carnosine, a complex consisting of a double bond of the amino acid histidine. Small amounts of alcohol also retard glycation. In fact, drinking a glass or two of red wine, which contains potent antioxidants called polyphenols, has many health benefits.

   One recent study showed that a nutrient in red wine, resveratrol, not only works against cancer and cardiovascular disease but also seems to retard calorie-restriction-induced aging. Before you go out and down a bottle of wine, though, be aware that the effect has thus far been noted in yeast only. Also, excess alcohol intake leads to toxic effects on all muscles in the body—including the heart.

   Reaching age 40 also demands that you eat the best-quality protein, including the usual bodybuilding staples of fish, chicken, lean beef and eggs. Emphasize fatty-fish sources, such as mackerel, salmon, herring and halibut, which have a higher content of omega-3 fatty acids. Omega-3 fatty acids provide numerous health benefits and also appear to modulate the body’s inflammatory processes. Recent studies also show that a regular intake of omega-3s helps maintain brain function with age, and people with the highest levels of omega-3 fats during middle age show the least amount of brain degeneration as they get older.

   The other type of essential fat, omega-6, offers some health benefits and is a direct precursor of substances that build and maintain muscle, such as prostaglandin F2A. It’s available in relative abundance in typical diets, but omega-3 is considerably scarcer. That explains the focus on omega-3 fat.

Those who cannot eat fish can get supplemental sources of omega-3 fats. Some advocate the use of flaxseed oil, which contains alpha-linoleic acid, a precursor of the active omega-3 fats EPA and DHA. Research, however, shows low conversion rates of alpha-linoleic acid into EPA and DHA, making it an overrated source of omega-3. The preferred supplemental form is fish oils, which are higher in EPA and DHA.


   Saturated fat, found in meat and other animal protein sources, is often linked to cardiovascular disease. It doesn’t oxidize in the body, but it acts as a substrate for the increased production of low-density-lipoprotein cholesterol in the blood. On the other hand, studies show that only two types of dietary fat help maintain testosterone levels in the body: saturated and monounsaturated fat. Keep saturated fat intake to no more than 10 percent of total daily calories.

   Far worse than saturated fat from a health and longevity standpoint are trans fats—fats that have been structurally manipulated to extend shelf life and prevent premature spoilage. The body handles them more or less as it does saturated fat; however, unlike saturated fat, trans fat lowers levels of protective factors in the body, such as high-density lipoprotein, which is a primary factor in preventing cardiovascular disease. Trans fats also promote cancer and lead to muscle breakdown by interfering with the synthesis of normal eicosanoids (substances made from fatty acids). Trans fats, found in such processed foods as margarine, shortening and commercial baked goods, are usually identified on food labels as “partially hydrogenated oils.”

   Monounsaturated fat, found in olive oil and many types of nuts, is considered a neutral fat in that it doesn’t adversely affect cardiovascular health or synthesis of prostaglandins, which are hormonelike acids that have far-ranging effects in the body. If anything, food sources of monounsaturated fat contain potent phenol compounds that provide antioxidant activity. That explains why monounsaturated fat is a cornerstone of diets linked to increased longevity and freedom from degenerative disease, such as the Mediterranean diet. That diet, by the way, along with the Paleolithic, or Stone Age diet constitute the two best year-round eating plans for maintaining health and muscle.

   Studies of men over 40 engaged in weight training clearly show a superiority of animal to vegetable protein sources. Animal protein has a better amino acid balance and is easier for the body to process, an important consideration for those over 40. For that reason, supplemental protein products should also feature the highest quality sources: a combination of the milk proteins casein and whey.

   Casein is a slow-acting protein that promotes a gradual release of amino acids over a seven-hour period. That timed release sets off an anticatabolic effect in muscle that’s particularly pronounced if you get the protein before sleep. The other milk protein, whey, is a more rapidly absorbed protein that peaks in the blood and is gone after about 90 minutes. The rapid absorption characteristics of whey lead to a rapid release of amino acids that favors increased muscle protein synthesis. That’s especially useful if you get the whey in a postworkout or even a preworkout drink.

   Protein synthesis becomes more difficult as the body ages. Studies that have compared eating several small meals to one or two meals show that eating smaller protein meals at regular intervals, such as every 2 1/2 to three hours, promotes increased muscle protein synthesis in younger men and women. Studies of those over 40 show that eating one or two larger protein meals seems to work better than eating smaller meals more often. Scientists think the larger meals release a greater amount of amino acids in older people, and amino acids are the key to promoting muscle protein synthesis. Unfortunately, the subjects of the studies were sedentary people not engaged in resistance exercise. So the information may not apply to those actively involved in weight training. More recent studies show that protein released from a meal lasts for about five hours, so you should ensure waiting no longer than five hours between protein meals.

Controversy surrounds the question of whether those over 40 should use soy products. Soy protein is inferior to animal protein sources, such as casein and whey, and acts like whey in that it’s rapidly absorbed and metabolized. Studies comparing the effects of soy and milk proteins show little difference from an anabolic standpoint. Soy protein, however, has a greater antioxidant effect after exercise than whey does. But other studies show that soy protein seems to boost protein synthesis more in internal organs, rather than muscle.


   Soy contains active ingredients collectively known as isoflavones, which have many beneficial health properties. In Asian countries, where soy products are in wide use, people average a daily isoflavone intake of 40 to 60 milligrams. Some studies show that soy guards against breast and prostate cancer. On the other hand, soy isoflavones are also known as phytoestrogens because of their structural similarity to estrogen. That’s where the controversy kicks in. While small amounts of a soy protein product—say, 25 grams a day—may help to prevent prostate cancer and cardiovascular disease, too much begins to mimic the undesirable effects of estrogen, such as water retention.

   Ignore all the dire warnings about the alleged dangers of a high-protein diet. A search of the medical literature regarding problems linked to high protein reveals that all cases involved people who had existing kidney problems. Since the kidneys—along with the liver—are the main organs that process protein, a high-protein diet can cause trouble when they’re not functioning properly. That doesn’t apply to those with normally functioning kidneys. If anything, one amino acid, L-arginine, may prevent the deterioration in kidney function that often occurs with advanced age. One theory is that arginine helps maintain local nitric oxide production in the kidneys, thereby maintaining optimal blood flow.

   Those over 40 typically complain of joint pain resulting from exercise. It may be due to arthritic changes in joints over the years or from glycation. Nutritional supplements may offer help: glucosamine sulfate (1,500 milligrams daily) and chondroitin sulfate (800 milligrams daily); MSM, 4,000 to 6,000 milligrams daily; and turmeric or curcumin, 3,000 milligrams daily. Like the COX-2 inhibitor drugs that have gained such a notorious reputation, curcumin offers potent anti-inflammatory effects; unlike them, curcumin isn’t linked to heart attacks. Curcumin also promotes the conversion of relatively inactive T4 thyroid hormone into the five times more active T3 version, which helps maintain metabolism and better body composition, meaning less fat.

   Flavonoids naturally found in grapeseed extract inhibit the enzymes that degrade joint proteins. Omega-3 fats also offer relief through decreased production of inflammatory mediators in joints. Green tea provides some joint protection through its antioxidant effect, known to be more than 50 times more potent than that of vitamin E.

   Perhaps the most vital component of nutrition for those over 40 is eating functional foods and neutracueticals; that is, foods that contain such elements as flavonoids, which help protect against degenerative diseases. One example is lycopene, a carotenoid found in tomatoes and other red fruits and vegetables. Studies show that lycopene works against prostate cancer and cardiovascular disease.

   The foods that offer the most protection are fruits and vegetables. The nutrients they provide include fiber, flavonoids and polyphenols, which are difficult or impossible to get from supplemental sources. The usual recommendation is to eat at least five servings a day of fruits and vegetables, with nine or more servings being ideal. But studies show that 75 percent of Americans don’t eat even the minimal five servings a day.

   Small wonder that cardiovascular disease and cancer continue to be the major killers of Americans. The only true antidote to such diseases is to exercise and eat fruits and vegetables. The older you are, the more important it is, since the onset of these diseases begins in earnest at about age 40. The processes that initiate them, however, start even earlier. As an example of just how protective such foods can be, a recent study showed that eating the following in one meal, termed a “polymeal,” can reduce the risk of cardiovascular disease by 76 percent:1



Wine, 150 milliliters a day

Fish, 114 grams, four times a week

Dark chocolate, 100 grams a day

Fruits and vegetables, 400 grams a day

Garlic, 2.7 grams a day

Almonds, 68 grams a day

   Following the nutrition principles outlined here ensures many years of successful training and health maintenance for those past 40 and beyond. The aging process is inexorable, but the quality of life is largely under individual control, with good nutrition and exercise being the keys to a higher quality of living.


1 Franco, O.H., et al. (2004). The polymeal: a more natural, safer and probably tastier (than the polypill) strategy to reduce cardiovascular disease more than 75%. Brit Med J. 329:1447-1450.

©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.


Have you been ripped off  by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at JerryBrainum.com.

 

The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at www.appliedmetabolics.com. This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.

 

See Jerry's book at  http://www.jerrybrainum.com

 

Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at www.appliedmetabolics.com

 

Let the NO Flow : What’s the best L-arginine dose for pumping you up? by Jerry Brainum


  L-arginine is a conditionally essential amino acid, meaning that it’s essential in the human diet under certain conditions—among them periods of rapid growth, pregnancy and after injuries. The liver synthesizes arginine during the urea cycle, which is involved in the excretion of protein-metabolism waste products. The arginine the process produces, however, isn’t available to the rest of the body. Instead, an arginine metabolite amino acid called L-citrulline circulates in the blood to the kidneys, where it’s converted back into L-arginine.


   L-arginine is present in most protein foods, and the average person consumes about five grams a day. It first became popular with bodybuilders about 25 years ago, after the publication of the book Life Extension by Durk Pearson and Sandy Shaw. They quoted studies showing that arginine is a potent stimulator of growth hormone release. An Italian study published a few years later showed that taking a supplement containing 1,200 milligrams of both arginine and L-lysine produced a 600 percent increase in GH release in 14 young men. The results of that study, however, have never been replicated. Most scientists discount the use of oral arginine as a GH promoter because most studies that have shown significant GH release involved a 30-gram intravenous infusion.

   More recently supplemental forms of L-arginine have been promoted as a nitric oxide booster. L-arginine is the immediate nutritional precursor of nitric oxide, which is a free radical and a type of gas that, among other things, acts as a potent dilator of blood vessels. The dilation of blood vessels gives you greater muscle pump during a workout, as well as increased nutrient and oxygen delivery to muscle.

   Absorption of L-arginine in the body isn’t straightforward, however. An enzyme in the liver called L-arginase degrades a large oral dose of arginine, which helps explain why an infusion is more effective in GH release than an oral dose. Another problem, more directly related to nitric oxide synthesis, involves the presence of methylated forms of arginine that actually inhibit nitric oxide synthesis during protein digestion. Thus, for arginine to effectively increase nitric oxide synthesis, you must get an oral dose sufficient to overcome the formidable barriers to its uptake.

   A new study sought to determine the optimal oral dose of L-arginine for purposes of nitric oxide synthesis.1 Twelve healthy people took free L-arginine for four weeks—free not because of price but because it wasn’t complexed with anything else, such as hydrochloric acid. (Oral intake of too much HCL causes gastrointestinal distress.)

   The subjects took increasingly larger doses of arginine—three, then nine, 21 and 30 grams a day. Researchers measured not only arginine levels but also insulin, creatinine and several other substances. Five subjects reported side effects that included diarrhea, vomiting and nosebleed at the 21-gram dose. At the 30-gram level two of the subjects refused it, while nine subjects reported diarrhea, one had a headache, and another complained of dry mouth. The lower doses produced no side effects except with one person who had a nosebleed.

   Arginine levels peak 60 minutes after oral intake and are still elevated after eight hours, though how much arginine is absorbed varies considerably. Based on their findings, the authors suggest that the best dose for ensuring nitric oxide synthesis is nine grams a day but caution that dosage must be tailored to each person. One way of doing that is to note the level of arginine that leads to side effects, then reduce it until the effects subside.

   Unlike previous studies, this one found that arginine—at any dose—didn’t promote the release of insulin, nor did it affect glucose metabolism in any way. The only amino acid arginine lowered was glycine. The authors think that since both glycine and arginine are precursors of creatine synthesis, the arginine may have increased that. (Creatine helps build muscle and is good for the neural and cardiovascular systems.) On the other hand, the lack of effect on levels of creatinine, a metabolic waste product of creatine synthesis that is excreted through the kidneys in urine, appears to discount that theory.

1Evans, R.W., et al. (2004). Biochemical responses of healthy subjects during dietary supplementation with L-arginine. J Nutr Biochem. 15:534-39.


©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.


Have you been ripped off  by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at JerryBrainum.com.

 

The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at www.appliedmetabolics.com. This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.

 

See Jerry's book at  http://www.jerrybrainum.com

 

Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at www.appliedmetabolics.com

 

Monday, November 7, 2011

Protein and gluconeogenesis: how important is it? by Jerry Brainum

One of the "secrets" of consuming a higher protein diet is that such diets appear to promote satiety, or depress appetite. In fact, this is one explanation of why when low carbohydrate diets are compared to low fat, high carb diets, the low carb diets lead to greater fat losses. Most people are hungrier on the low fat plans, which often skimp on protein intake. The high protein aspect of low carb diets is also considered a feature of the diet because the greater protein intake is thought to spare vital lean mass, including muscle. Studies show that if you ingest a larger intake of protein, over half the excess protein that you ingest will be converted to glucose in the liver in a process called gluconeogenesis. This is one reason why carbohydrates aren't considered essential in human nutrition. The liver can convert other substances into glucose, the only type of sugar that circulates in the blood. These other substances include amino acids from protein, lactate, ketones from fat metabolism, and glycerol, which comprises 10% of the triglyceride (fat) structure.
    The usual figure in relation to how much ingested protein is converted into glucose in the liver is about 57% of ingested calories as protein. However, a new study casts doubt as to the extent of this conversion. The study involved 8 human subjects, who first fasted overnight. Fasting overnight reduces the liver stores of glycogen, which is broken down to provide glucose when carbohydrates aren't consumed, such as when you are sleeping. As such, liver glycogen stores are relatively low when you awaken, assuming that you haven't eaten anything throughout the night. After awakening, the eight subjects were intravenously infused with radioactively labeled glucose. Two hours later, they ingested a 4-egg omelet, which also contained tracers to follow the fate of the ingested protein. This meal contained 23 grams of protein. The researchers examined the production of glucose from the meal for 8 hours.
      What they found was that the endogenous production of glucose didn't change after the meal, despite the metabolism of the proteins contained in the meal. The production of glucose in the body declined after 6 hours. The maximal contribution of amino acids from the meal to glucose production in the body occurred between 3 and 5 hours after the meal, representing only 5% of the glucose produced in the body during that time. Of the 53 grams of glucose produced over 8 hours, 1.8 grams originated from the ingested protein meal.Based on this, the study authors concluded that protein and fat eaten alone do not significantly contribute to glucose production in the body. They did not disclose where the other 52 grams of glucose that were produced over 8 hours came from, but it likley came from other sources, such as lactate or glycerol, or perhaps from breakdown of glycogen in the liver.
      This study would seem to indicate that the contribution of protein to glucose production has been overplayed. However, the study also shows that despite little contribution from the egg meal to glucose production, glucose was still produced from something, but it wasn't from protein. I suspect that since the subjects only fasted overnight, that they still had sufficient glycogen remaining in their livers to contribute to the glucose production. It would be more interesting to have them eliminate all carbs for at least a week or so, then test for the fate of ingested protein. If the body still has a source of glucose, such as liver glycogen stores, there would be little or no need to convert ingested proteins into glucose, as was shown in this study. On the other hand, if it turns out that ingested protein doesn't significantly contribute to glucose production, it would mean that the warnings about muscle protein breakdown during extended low carb diets may be true after all. That awaits further research, however.

Fromentin,C , et al. Dietary proteins poorly contribute to the endogenous production of glucose after egg ingestion in humans.Ann Nutr Metab2011;58(supp1);319.


©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.


Have you been ripped off  by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at JerryBrainum.com.

 

The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at www.appliedmetabolics.com. This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.

 

See Jerry's book at  http://www.jerrybrainum.com

 

Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at www.appliedmetabolics.com

 

Saturday, November 5, 2011

TRAIN TO GAIN : Less Rest for a GH Surge?..Growth hormone release during training by Jerry Brainum

   A study presented at the NSCA conference by researchers from the University of Connecticut examined whether taking short rests between sets influences the release of growth hormone during exercise. The subjects were 10 bodybuilders with at least four years of training experience and 10 untrained but physically active men. The bodybuilders had previously trained on programs that featured short rests between sets. For the study both groups did six sets of 10 reps on the squat, resting two minutes between sets.


   Both the trained and untrained men showed similar resting GH levels, and both groups showed a significant rise in the hormone after the workout. The trained men, however, produced more lactic acid, which stimulates GH release during exercise. The ability to train at higher level of lactic acid release appears to enable more-experienced bodybuilders to produce a superior GH response to exercise.
    Recently, several studies have appeared that downplay the role of an exercise-induced anabolic hormone increase. According to these studies, the transitory increases in levels of growth hormone and testosterone after intense exercise doesn't appear to play as important a role in promoting gains in muscular size and strength as was previously believed. These researchers instead say that what's really important is the intensity level of the exercise and the force of muscular contractions, both of which promote an upgrading of muscle protein synthesis. It's the upgraded muscle protein synthesis resulting from exercise, rather than the rise in anabolic hormones, that is the key player in promoting gains in muscular size and strength. Or so say these researchers. What is undeniable, however, is the role of autocrine or intramuscular release of anabolic hormones induced by exercise. These include two variants of  insulinlike growth factor-1 (IGF-1), namely IFG-1Ea and mechano growth factor (MGF). These locally produced anabolic hormones are essential for the use of muscle satellite cells, which are a type of stem cell used for muscle repair and growth.In this sense, anabolic hormones, at least that produced within muscle, are important and vital for promoting muscle gains.


©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited. 


Have you been ripped off  by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at JerryBrainum.com.

 

The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at www.appliedmetabolics.com. This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.

 

See Jerry's book at  http://www.jerrybrainum.com

 

Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at www.appliedmetabolics.com

 

 

Friday, November 4, 2011

La Dolce Eater : The Mediterranean Diet: Is It the Most Healthful Eating Plan Known to Man? by Jerry Brainum

Antonio Todde would probably have lived his life in total obscurity had someone not found his birth certificate. It proved that the shepherd from Sardinia, at age 111, was the oldest man in the world. When told of his distinction, the curmudgeonly Todde responded by asking, “You have come all this way to tell me that I’m the oldest man? Who says so?”


   When scientists examined the possible reasons for Todde’s longevity, several factors emerged. Genetics undoubtedly played a role: One of Todde’s sisters was 100 years old, and his father had lived to 90. His mother might have made it past 100 had she not eaten a piece of poisoned cheese at age 99. Sardinia, the island off Italy where Todde spent his entire life, was known for its unusual abundance of centenarians. Was it the simple, relatively stress-free life that enabled Sardinians to live so long?

   Perhaps. On the other hand, a scientific project designed to identify the secrets behind Sardinian longevity found that most of the older people on the island also had a deficiency of an enzyme called glucose 6PD, which can cause a disease marked by rapid destruction of red blood cells should a person with the deficiency eat (of all things) fava beans. Somehow, the enzyme deficiency interacted with other genes to confer long life. Antonio Todde had a far simpler explanation: “You take one day after the other; you just go on. Just love your brother and drink a glass of good wine.”

   Todde’s diet, as it turned out, was in keeping with current theories about the interaction between what you eat and how long you live. He didn’t take in too many calories, basing his diet on pasta and soup. He did have some pork or lamb each day in moderate amounts, always including a glass and a half of red wine. His diet was a version of what’s known as the Mediterranean diet.

   The Mediterranean diet is named for the eating style prevalent in European countries abutting the Mediterranean Sea, especially Greece, Italy, the south of France and Crete. It has some of the best features of the Zone diet, as well as the Paleolithic, or Stone Age, diet, both of which have been discussed in detail in past issues of IRON MAN. What the diets have in common are natural elements that empower the human body to maintain health, energy and longevity.

What Is the Mediterranean Diet?

   Like the Paleolithic diet, the Mediterranean diet has been around for thousands of years. It’s big on high fiber intake, mainly from fruits and vegetables, and moderate intake of whole grains. It boasts a moderate fat content, averaging between 30 and 35 percent of total daily calorie intake, precisely the same as the Zone diet. Also like the Zone diet, it emphasizes decreased saturated-fat intake and a higher intake of monounsaturated fat, mainly in the form of extra virgin olive oil. It features lowfat, high-protein sources, such as chicken and fish, with a moderate intake of red meats. The high-fiber fruits and vegetables are rich sources of natural antioxidants that research shows offer potent protection against the two major killers, cardiovascular disease and cancer.

   Rigorous research has confirmed the protective effects of the Mediterranean diet against cardiovascular disease. The Lyons Diet Heart Study featured 605 people who had previously suffered a heart attack. After four years on a Mediterranean diet rich in alpha-linoleic acid, an omega-3 fat source and monounsaturated fat, the patients showed a 55 percent reduction in the risk of death, with 50 percent to 70 percent less risk of recurrent cardiovascular events than other patients not on the Mediterranean diet. The benefits couldn’t be explained by changes in blood fats, such as cholesterol. The GISSI-Prevenzione trial showed that those who went on a Mediterranean diet had more favorable survival rates after four years. Analysis of the diet showed that its active components included fish, fruit, vegetables and olive oil.

The Fat Connection

   The so-called good fats, such as omega-3 fats derived from fish and the monounsaturated fat in olive oil, are primary components of the Mediterranean diet. Omega-3 fats are known to have various cardiovascular-protective effects, such as lowered triglycerides, or fat, in the blood and reduction of heart-rhythm disturbances. Trans fats, which have been structurally manipulated to increase the shelf life of (mostly processed) foods, are notably missing from the Mediterranean diet. Trans fats may decrease the oxidation that promotes spoilage and rancidity, but they’re the worst type of fat to eat. They’ve been linked to both cardiovascular disease and cancer. They’re even worse than the much maligned saturated fats: While both forms of fat increase low-density-lipoprotein cholesterol, or LDL, which is associated with cardiovascular disease, trans fats also lower protective high-density-lipoprotein cholesterol, or HDL.

Nuts are integral to the Mediterranean diet. As noted in recent IRON MAN features on nuts, they’re not the demonic food that so many people believe they are. Sure, they’re high in fat, but always the more beneficial monounsaturated and polyunsaturated fats—never the saturated form. Nuts are also rich in other protective nutritional elements, such as fiber, vitamin E, folic acid, potassium and magnesium.


A Little Vino—and Other Beneficial Features

   A happy feature of the natural Mediterranean diet is that it permits a regular intake of moderate amounts of alcohol, mainly red wine. Red wine is rich in antioxidants called polyphenols, which exert potent protective effects and, with the alcohol itself, increase HDL. One study found that men who drink five or six alcoholic beverages a week had a 20 percent lower risk of mortality than nonimbibers.

   The Mediterranean diet’s chief benefit seems to be that it contributes to a significant reduction in tissue inflammation.1 That’s because research has confirmed that out-of-control inflammation is at the core of most serious forms of disease, including cardiovascular disease, cancer and Alzheimer’s.

   A study published last year examined 1,514 men, aged 18 to 87, and 1,528 women, aged 18 to 89, from the Attica area of Greece who had regularly adhered to a Mediterranean diet. Comparing them with subjects who had not followed the diet, the researchers found that those who followed the Mediterranean plan showed an average of 20 percent less C-reactive protein, a major marker of overall inflammation in the body. They also had 17 percent lower levels of interleukin-6, an inflammatory cytokine, or protein, linked to high cortisol levels, and had lower levels of other inflammatory blood markers, such as homocysteine and fibrinogen.

   Another study looked at all the elements of the Mediterranean diet related to heart attacks and concluded that one of its major benefits was high fiber intake.2 In fact, those who ate the most fiber while on the diet were a whopping 86 percent less likely to suffer a major heart attack. “Our data suggest that a substantial part of the postulated benefits of the Mediterranean diet on coronary risk might be attributed to a high intake of fiber and fruit,” wrote the primary author of the study.

The Big Benefits of Using Olive Oil

   Still, the food element most linked to the protective effect of the Mediterranean diet is virgin olive oil, a monounsaturated fat with phenol compounds. One study found that taking in a minimum of 25 milliliters a day of virgin olive oil would lead to reduced oxidation of the dreaded cardiovascular-disease-prone LDL.

   Monounsaturated fat, the kind found in olive oil, is less subject to oxidation than other food oils and has a neutral effect on blood lipids, meaning that it doesn’t lower HDL in the blood. As Zone author Barry Sears notes, monounsaturated fats don’t adversely affect the synthesis of fat-based chemicals in the body collectively known as eicosanoids. That means monounsaturated fat protects against both cardiovascular disease and cancer. One scientist has estimated that up to 25 percent of the incidence of colorectal cancer, 15 percent of breast cancer and 10 percent of the incidence of prostate, pancreatic and endometrial cancers would be prevented if people adopted the Mediterranean diet eating style.

   Monounsaturated fat exists in foods that don’t pack olive oil’s punch. Many scientists think that what sets virgin olive oil apart is its unique blend of antioxidant phenol compounds, such as oleuropein and hydroxytyrosol, which promote decreased oxidation of LDL in the blood. Olive oil also helps lower blood pressure, and it contains squalene, a substance that guards against various cancers, including skin cancer. Like prescription statin drugs, squalene inhibits the liver enzyme that synthesizes cholesterol from saturated fat and prevents the proliferation of smooth muscle within arterial walls, which narrows blood vessels and promotes heart attacks and strokes.

You’ve seen lots of olive oils on supermarket shelves, but extra virgin oil is what you want. Other types don’t have the phenols. You also need to be realistic about what olive oil can do for you. A recent meta-analysis of previously published studies explained that the amount of olive oil used in the typical Mediterranean diet is too small to provide significant antioxidant benefits,3 which underscores the fact that no single element of the Mediterranean diet works magic. Rather, the protective nutrients work in a synergistic fashion.


But Can It Work for Bodybuilders?

   From a bodybuilding perspective, the Mediterranean diet can be used year-round. Prior to a contest, you would simply need to reduce calories. In actual practice those who follow the diet year-round would likely have low bodyfat levels, making any type of stringent precontest diet superfluous.

   The generous intake of natural, unprocessed foods means that your food supplement budget would also be considerably reduced. You would need to include nutrients not found in abundance in natural foods, such as vitamin E. Adding a high-quality protein supplement would also be an excellent idea, since such products contain almost no carbs.

   Following a Mediterranean diet may not allow you to live to 112, as it did for Antonio Todde, unless you also share his genes, but it will assure you of maximal health, help you avoid most degenerative diseases and permit you to develop a body rich in muscle and very low in fat.

References

1 Chrysohoou, C., et al. (2004). Adherence to the Mediterranean diet attenuates inflammation and coagulation processes in healthy adults: the Attica study. J Amer Coll Cardio. 44:152-158.

2 Martinez-Gonzalez, M., et al. (2002). Role of fiber and fruit in the Mediterranean diet to protect against myocardial infarction: a case-control study in Spain. Eur J Clin Nutr. 56:715-722.

3 Vissers, M.N., et al. (2004). Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr. 58:955-965.


©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.


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