Wednesday, September 14, 2011

Exercise and Cancer Answers by Jerry Brainum

Prostate cancer is the number-two killer of men, just after lung cancer. Several studies have shown that exercise appears to offer preventive effects against the disease. Most studies attribute that to a decrease in testosterone induced by exercise (usually endurance training). Although the finding is still controversial, testosterone is in fact linked to prostate cancer. Some scientists believe that testosterone itself isn’t the villain but rather dihydrotestosterone (DHT), the testosterone by-product linked to acne and male pattern baldness.

A recent study has identified another mechanism.1 Researchers found that exercise enhances the function of a gene in the body called P53, which is known to “kill” cancer cells by arresting the growth of tumors and promoting their suicide, a process called apoptosis. When the blood serum after exercise was analyzed, apoptosis in prostate cancer cells increased by 371 percent, and P53 protein increased by 100 percent. Thus, exercise can help prevent prostate cancer by upgrading the body’s innate defense system against tumor formation.

1 Pak-Shan, L., et al. (2004). Exercise alters the IGF axis in vivo and increases P53 protein in prostate tumor cells in vitro. J App Physiol. 96:450-54.

©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.

Have you been ripped off  by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at


The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.


See Jerry's book at


Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at