Sunday, October 16, 2011

Can leucine spare muscle lost from aerobic training? by Jerry Brainum

Many bodybuilders fear doing aerobics because they think it will lead to a loss of hard-earned muscle mass. Looking at long distance runners, with their anorexic-appearing bodies, seems to confirm this notion. In addition, some studies that have involved human subjects have indeed found several catabolic processes at work with extended aerobic work. These studies show that doing excessive amounts of aerobics boosts levels of cortisol, the primary catabolic hormone in the body. As cortisol levels rise, testosterone levels tend to drop. Since testosterone helps to build and maintain muscle mass, it's not hard to understand why going overboard with aerobics can lead to muscle mass losses.
    But the key word here is "overboard." Cortisol levels don't begin to rise during aerobics until after about an hour of steady aerobics. If you do less than that in one session, the rise in cortisol is negligible. There is an exception to this, however. Those on either restricted low calorie diets, or diets very low in carbohydrate, would have a higher release of cortisol during aerobics because of the restricted energy intake features of both diets. In addition, just lifting weights also boosts cortisol, particularly near the end of the workout. This workout-induced rise in cortisol, however, tends to occur more in less experienced trainees. With training experience, the body tends to adapt to regular exercise, and as a result less cortisol is produced during and after the workout session.
     Another reason why there's a greater chance of losing muscle with aerobics is because muscle protein synthesis ceases during aerobics (and weight-training as well). The reason for this is that as far as the body is concerned, energy production is more vital than muscle protein synthesis. So the primary focus during exercise is maintaining energy to power the muscle activity. One way the body does this, besides cortisol release, is through the release of a protein called AMPK. AMPK functions as an energy sensor in muscle, and when levels of ATP decline in muscle, AMPK is secreted. Among other functions, AMPK promotes the use of fat as a fuel, which is a primary goal of aerobic exercise. But the other side of the coin is that AMPK also abruptly halts all protein synthesis. Since the body mantains a balance between anabolic and catabolic processes, if protein synthesis ceases during exercise, catabolic or breakdown processes begin to dominate.
     But there may be a easy nutritional antidote to this dilemma. A new study had 10 subjects who ingested a protein drink containing 10 grams of protein, with either 1.87 or 3.5 grams of added leucine during a cycling test. Leucine is one of three branched-chain amino acids, and is the amino acid most associated with increased muscle protein synthesis. It does this by promoting the activity of another protein called mTOR. Another group of subjects drank an essential amino acid drink with no added leucine. Those in the leucine group showed a 33% increase in muscle protein synthesis. The leucine group also showed less muscle protein breakdown during exercise. It's important to note that this effect is mainly associated with aerobic exercise of extended duration, not weight-training. But it also means that those who fear losing muscle from doing aerobics while in restricted calorie or carb diets can supplement with leucine prior to the aerobic session, and not only not lose any muscle, but actually boost muscle protein synthesis by a third.

Pasiakos, SM ,et al. Leucine-enriched essential amino acid supplementation during moderate  steady state exercise enhances leucine-enriched muscle protein synthesis, Am J Clin Nutr 2011;94:809-818.


©,2013 Jerry Brainum. Any reprinting in any type of media, including electronic and foreign is expressly prohibited.

Have you been ripped off by supplement makers whose products don’t work as advertised? Want to know the truth about them? Check out Jerry Brainum's book Natural Anabolics, available at JerryBrainum.com

 
 

The Applied Ergogenics blog is a collection of articles written and published by Jerry Brainum over the past 20 years. These articles have appeared in Muscle and Fitness, Ironman, and other magazines. Many of the posts on the blog are original articles, having appeared here for the first time. For Jerry’s most recent articles, which are far more in depth than anything that appears on this blog site, please subscribe to his Applied Metabolics Newsletter, at www.appliedmetabolics.com. This newsletter, which is more correctly referred to as a monthly e-book, since its average length is 35 to 40 pages, contains the latest findings about nutrition, exercise science, fat-loss, anti-aging, ergogenic aids, food supplements, and other topics. For 33 cents a day you get the benefit of Jerry’s 53 years of writing and intense study of all matters pertaining to fitness,health, bodybuilding, and disease prevention.

 

See Jerry's book at  http://www.jerrybrainum.com

 

Want more evidence-based information on exercise science, nutrition and food supplements, ergogenic aids, and anti-aging research? Check out Applied Metabolics Newsletter at www.appliedmetabolics.com